Bayer case2 Essay Example for Free

Bayer case2 Essay Supply chain factors must also be taken into account in the decision-making if substantial capacity changes are involved – like reintroducing Bayer Aspirin. Key questions include: What impact will the changes have on suppliers, warehousing, transportation, and distributors? If capacity will be increased, will these elements of the supply chain be able to handle the increase? Conversely, if capacity is to be decreased, what impact will the loss in business have on these elements of the supply chain? Finally, customer and public opinion is very crucial to consider during decision-making. Will they still accept the new reintroduced product as before? What would be the common sentiments of the people regarding the possible decision? In evaluating alternatives during decision-making, a manager must consider both quantitative and qualitative aspects. Quantitative analysis usually reflects economic factors, and qualitative considerations include intangibles such as public opinion and personal preferences of managers. Thus, in deciding for the Bayer Aspirin case, is not solely dependent on economic factors because these are not the only things that would be affected when changes are being implemented. As an organization, Bayer should draw out what are the quantitative and qualitative considerations at hand, in order to come up with efficient and effective decisions for their company. 4. ) In what ways is Aspirin Brand valuable for Bayer? When aspirin first appeared in the spring of 1899 in a handful of articles in a few German medical journals, the author introduced it without fanfare as a serviceable substitute for the salicylic acid and sodium salicylate that had been in use for more than twenty years to treat rheumatic disorders. Aspirin reduced fever and inflammation quickly, but more importantly it did not appear to have an ill effect on the stomach. Side effects were minimal, so patients tolerated it quite well and they did not rebel against the treatment. The doctors who tested it and the company that manufactured it therefore recommended the drug as a promising anti-rheumatic medication and no doubt expected respectable profits from its use in this modest market. No one, however, apparently anticipated that in less than two decades this new compound would become the manufacturers best-selling medicine and the worlds most widely used drug (a distinction it still holds), not so much because of its role in treating rheumatism but because of its effectiveness in managing minor pain, especially headaches. And by the time Aspirins overall popularity was apparent, it was also apparent that it had achieved this exalted status not simply because of its considerable medical merits but also because of the deliberate business policies and practices of its manufacturer, the Farbenfabriken vormals Friedrich Bayer und Companie of Elberfeld, Germany, or simply known as Bayer. Headquartered in Leverkusen, Germany, Bayer is involved in 20 different business units that research, develop and manufacture products in the life sciences, polymers and specialty chemicals areas. Considered as the â€Å"jewel† at the very center of the Bayer crown, Aspirin is more than just a brand name that Bayer acquired. It is without question the most successful over-the-counter drug in history. In fact, 1999 marked the 100th anniversary of Aspirin, it is still the number two analgesic drug in the world with net sales in 1998 of DM1. 1 billion (US$654. 8 million). Only Tylenol exceeds ASPIRIN in sales, but 95% of Tylenols sales are in the US; in the rest of the world, Bayer is still number one (Buchanan and Merker, 2002). As a brand, its popularity is undeniable around the world. Exhibit 3 shows that the market of Aspirin covers 90 countries. At present, Bayer Aspirin is a family of well-known brands and products, which includes Childrens ASPIRIN ®, ASPIRINProtect ®, ASPIRIN Direct ®, ASPIRIN+C ®, and many others. All are geared for specific uses such as cough and cold, headache and pain, stroke and heart attack prevention. Many have unique delivery systems such as granules, effervescent tablets, and chewable forms. Of the US$654. 8 million in total worldwide net sales of all Aspirin products in 1998, US$37. 5 million (5. 8%) came from the sale of Childrens ASPIRIN ®. In reality, Aspirin as brand propelled Bayer’s success all throughout its history. By promoting Aspirin (not acetylsalicylic acid), Bayer had foreseen that the brand name would be so firmly entrenched in the medical community that when the patent expired, rival manufacturers of ASA would be unable to compete in the American market. True enough that by 1909, Aspirin accounted for 31% of Bayers US sales. Although Bayer continues to hold a trademark on the brand name in many countries of the world, it had once lost that right in several key countries like the United States. Bayer trademark was lost initially in the US at the end of World War I to Sterling Drug, Inc. as the result of the US governments retaliatory practice of confiscating and then auctioning off the property of German companies with holdings in the United States. It wasnt until 1994, 76 years after the expropriation of the trademark Bayer Aspirin, that Bayer Group finally reacquired the brand. According to the Bayer Website, Bayer continues to look for new possibilities for Aspirin, being considered as the miracle or wonder drug. In 1988, Australian epidemiologist Professor G. Kune discovered that people who took Aspirin had a 40% lower incidence of colon cancer than those who did not. Later, a number of studies, including a large-scale study conducted by the American Cancer Society, confirmed that Aspirin is indeed effective in preventing colon cancer. According to one estimate, Aspirin inhibits cell mutation, a theory that paves the way for future research and the promise of new developments. Research is also being conducted into Aspirins effects on Alzheimers Disease and diabetes. Thus, Aspirin’s value for Bayer do not just depend on the brand name itself, but all its hidden potentials that could benefit all sick people because of its low price and time-tested usefulness. 5. ) How is the pharmaceutical market and the market for Aspirin evolving? Is it to the advantage or disadvantage of pharmaceutical companies? Originally prescribed for rheumatic disorders, aspirin has come a long way of just adrug marketed to reduce fever and inflammation quickly. As a drug, aspirin not only has the properties of an analgesic or painkiller, it is also an antipyretic (anti-fever), an anti-inflammatory and an anti-platelet (see Table 1). The first three qualities make it a headache, cold, and flu medication, but it is the fourth quality that makes Aspirin a preventive medication. Interestingly, the anti-platelet effects of aspirin occur at a surprisingly low dosage: 30-50 mg. or so, and Children’s ASPIRIN is one of the lowest dose aspirin products on the market. It also happens to be the cheapest among the ASPIRIN family of products. The significance of these two characteristics gave Children’s ASPIRIN a new market, as doctors around the world started recommending and prescribing Children’s ASPIRIN to their middle-aged patients as a means of prevention.

Expanding the Common Ground of the Worlds Mystical Traditions :: Culture Globalization Essays

Expanding the Common Ground of the World's Mystical Traditions missing works cited ABSTRACT: This paper addresses religious epistemology in that it concerns the assessment of the credibility of certain claims arising out of religious experience. Developments this century have made the world’s rich religious heritage accessible to more people than ever. But the conflicting religious claims tend to undermine each religion’s central claim to be a vehicle for opening persons to ultimate reality. One attempt to overcome this problem is provided by "perennial philosophy," which claims that there is a kind of mystical experience common to all religious traditions, an experience which is an immediate contact with an absolute principle. Perennialism has been attacked by "contextualists" such as Steven Katz who argue that particular mystical experiences are so tied to a particular tradition that there are no common mystical experiences across traditions. In turn, Robert Forman and the "decontextualists" have argued that a certain kind of mystical experience and process are found in diverse traditions, thereby supporting one of the key elements of perennialism. I review the contextualist-decontextualist debate and suggest a research project that would pursue the question of whether the common ground of the world’s mystical traditions could be expanded beyond what has been established by the decontextualists. The extension of this common ground would add credibility to the claims arising out of mystical experience. It is appropriate at this conference to address — however narrowly and briefly — an important twentieth-century development in the world's religious life. Advances in scholarship, communication, transportation, and mass education have made the richness of the world's religious heritage accessible to more people than ever before. But this increased accessibility has not strengthened religious belief, but may, in fact, have had the opposite effect. This is because the revolution in accessibility to the world's religious traditions has made more people than ever before aware of the conflicting claims of the world's religions. Of course, each tradition's adherents believe their tradition to be the primary expression of the truth, but there seems to be no obvious "non-partisan" way to determine which tradition has superior credentials. Thus the conflicting claims of competing religious traditions tend to undermine each religion's central claim that it is a vehicle for openin g oneself to ultimate reality. One attempt to overcome this problem is provided by "so-called perennial philosophy school," to use the term used by Robert K.

City of Mumbai (Bombay) Essay

Towns and cities have a long history in our world, but opinions vary on whether any particular ancient settlements can be considered to be a city. The first true towns are sometimes regard as large settlements where the populations were no longer simply farmers of the surrounding area, but began to take on specialized occupations, and where trade, food storage and power was centralized. By definition of the city, the first we know of were located in Mesopotamia and in Egypt along the Nile. Before this time it was uncommon for communities to reach considerable size, although there were exceptions such as Jericho and Mehrgarh. Among the early cities, Mohenjo-daro of the Indus Valley Civilization was the largest, with an estimated population of 41,250 , as well as the most developed in many ways, as it was the first to use urban planning, municipal governments, grid plans, drainage, flush toilets, urban sanitation systems, and sewage systems. Our course examines politics and government of selected cites such as Chicago and Miami, this paper will shed light on Mumbai, one the world’s most important and fastest growing city. Mumbai is the most populated city in the all of India and the home of world renowned Bollywood, yet there are still many that have never even heard of the city. This is mostly due in fact to its recent name change; the majority of people around the world still refer this city as Bombay but in 1995 the major city went under a name change and now goes by the name of Mumbai. Present-day Mumbai was originally a group seven islands, and artifacts found near Kandivali, in northern Mumbai indicate that these islands had been inhabited since the Stone Age. Documented evidence of human habitation dates back to 250 BC, when it was known as Heptanesia. In 1534, the Portuguese took over the islands from Bahadur Shah of Gujarat, and named it Bom Baia, Portuguese for â€Å"good bay†. In 1668 these islands were leased to the British East India Company which founded a deep harbor on the east coast of the islands to be ideal for setting up their first port in the sub-continent. Not long after, the population rose from 10,000 in 1661, to almost 6 times that in the next fifteen years. The year 1869 marked the opening of the Suez Canal, which transformed Bombay into one of the largest seaports on the Arabian Sea. Over the next few decades the city grew into a major urban centre, this was spurred by major improvements in infrastructure and the  construction of many of the city’s institutions. India’s independence in 1947 labeled the city as the official capital of Bombay State, and in 1950 with the incorporation of the southern parts of Salsette Island, the city expanded to its present limits. Until the 1970s Calcutta remained as India’s most populous city, but thanks to a construction boom and a significant influx of migrants, Bombay would overtake Calcutta and to this day hold the title of India’s most populous city. And finally as stated earlier, in 1995, the city was renamed Mumbai by the government of Maharashtra, in keeping with their policy of renaming colonial institutions after historic local appellations. As of today the population of Mumbai is approximately 13 million, with a staggering density of roughly 29,000 persons per square kilometer. The ratio of women to men is about 81%; this gap is created by working males who come from rural areas. Mumbai’s overall literacy rate is above 86%, which is higher than the national average. Another surprising figure is the low crime rate; for a city of its size, Mumbai has a moderate crime rate. Mumbai recorded 27,577 incidents of crime in 2004, which is down 11% from 30,991 in 2001. The most common language spoken on streets of Mumbai is an informal form of Hindi, known as Bambaiya, which can be best described as a blend of Hindi, Marathi, Indian English and some invented words. Unfortunately, Mumbai suffers urbanization problems resembling those in many fast growing cities in developing countries such as the ones we study in the course. Issues of widespread poverty, poor public health and high unemployment affect a large section of the population. Also, with little available space to live, Mumbai inhabitants often reside in overcrowded, yet expensive housing, usually far from workplaces, which leads them to make long commutes on crowded mass transit, or clogged air polluted roadways. According to the Business Week, around 45-48% of the population lives in shantytowns and slums. Mumbai is known across the world as the commercial, but primarily, entertainment capital of India. When focusing on Mumbai it’s impossible to ignore its entertainment industry. Most of India’s major television and satellite networks are headquartered in Mumbai, as well as its major  publishing houses. It is hard to find someone, even all the way here in Montreal that hasn’t seen a Bollywood movie. But its not all lights, camera, action in Mumbai, the city also houses important financial institutions, such as the Reserve Bank of India, the Bombay Stock Exchange, the National Stock Exchange of India as well as the corporate headquarters of many Indian companies. Thanks to its immense business opportunities and the relatively high standard of living Mumbai has attracted people from all over India and around the world which makes it a hodgepodge of diverse communities and cultures. The bulk of Mumbai’s prosperity is no longer due to the textile mills and the seaport, the local economy has been diversified to include financial services, engineering, diamond polishing, healthcare and information technology. MumbaÄ « contributes 10% of India’s factory employment, 40% of income tax collections, 60% of customs duty collections, 20% of central excise tax collections, 40% of foreign trade and Rupees 40 billion (US$ 9 billion) in corporate taxes. The city is run by the Brihanmumbai Municipal Corporation (BMC) (formerly the Bombay Municipal Corporation), with executive power vested in the Municipal Commissioner, who is an IAS officer appointed by the state government. The Corporation comprises 227 directly elected Councilors representing the twenty four municipal wards . Mumbai isn’t immune to the commuting nightmares that face the citizens of most modern-day metropolitans. The general public, even those considered the upper class, rely on public transport to travel to and from their workplace. The lack of car parking spaces, horrendous traffic and poor road conditions makes it pointless for even those who can afford it, to own a vehicle. None the less, MumbaÄ « is a very unique city, already over 13 million citizens it continues to grow but at the same time continues to prosper and become one of the greatest cities of the 21st century.

A Cell With Mutation Essay - 926 Words

3. What might you expect to find in a cell with mutation that yielded the following organelles (1) 50% functional and (2) non-functional. Justify your answers. Mitochondria, rough ER, smooth ER, Peroxisomes, Golgi, and Chloroplasts. In Eukaryotic cells, organelles play a major part in function and maintenance. If parts of these organelles are not functioning properly, or at all, major issues could be caused within that cell. The mitochondria is known as the â€Å"power house† of a cell that functions at the site of respiration. Within the inner membrane, ATP synthesis occurs which provides energy to the cell and it other parts. Without function of a mitochondria, a cell would die; it has no energy to repair itself, has no energy to transport molecules across the membrane, transport nutrients, send signals to other cells, or any other processes. Metabolism, release of energy, movement, or forming new nucleotides would not occur simply because energy is not available. The rough ER is a connected system that is the site of protein synthesis. Proteins are a part of all processes in life including break down of food, aerobic respiration, transport of molecules through the body, glycolysis, DNA replication, DNA folding, and many more. If the rough ER of a cell was non-functional, a cell would not produce the proteins needed for these processes, therefore, in a human, many bodily functions would not occur which could eventually lead to death. Plants may also die because theirShow MoreRelatedThe Mutation of Cancer Cells Essay1766 Words   |  8 Pagescolon cancer, Cancer that forms in the tissues of the colon. Most oncogene mutations of indisputable normal genes designate proto-oncogenes. Proto-oncogenes determine the â€Å"excellent† genes that usually rule what cell do and the way typically it distribute. Once a factor mutates (changes) into cell, it come back a hurtful factor that may become usefulness on or activated once its not believe to be. Once this occurs, the cell becomes out of management, which might pass to cancer. As scientists learnRead MoreCell Replication And Gene Mutation986 Words   |  4 PagesGrodzinski, 2010). Based on the cancer overlook disease, the cells a re transformed and infected to cancer after a while and it starts to metastasize and proliferate (ibid). The cardinal issue is that how cancer may occur based on transformation of cells and genes. To illustrate that question, there are two factors that must be carried out together preemptory; one is cell replication and gene mutation and both of which results in programmed cell death, apoptosis. (Mansoori, Mohazzabi, McCormack, and JabbariRead MoreWhat Is Mutation? What Is a Gene Mutation? Discuss Sickle Cell Anemia (Its Cause, Effect, and Treatment) B) What Are Mutagens and Their Effects? C) What Is Genetic Counseling? Discuss the Advantages and Disadvantages of This Procedure.873 Words   |  4 PagesA mutation can simply be put as abrupt change in the genotype of an organism that is not the result of recombination. A gene mutation is a permanent change in the DNA sequence that makes up a gene. Mutations range in size from a single DNA building block (DNA base) to a large segme nt of a chromosome. Gene mutations occur in two ways: they can be inherited from a parent or acquired during a persons lifetime. Mutations that are passed from parent to child are called hereditary mutations or germRead MoreSCID Essay1149 Words   |  5 Pages Genetic testing has found various genes in which a mutation can occur to cause SCID. These genes include the JAK3, IL7R, ADA, RAG1, RAG2, DCLRE1C, LIG4, and IL2RG genes. (Lebet et al. 2008) The cytogenic locations of these genes in the order that they are presented above are as follows: 19p13.11 (NIH Genetics Home Reference, 2017e), 5p13.2 (NIH Genetics Home Reference, 2017d), 20q13.12 (NIH Genetics Home Reference, 2017a), 11p12 (NIH Genetics Home Reference, 2017g), 11p12 (NIH Genetics Home ReferenceRead MoreThe Theory Of Cancer Stem Cell Theory991 Words   |  4 Pagesabout how cancer grows to form tumors. The cancer stem cell theory states that tumors are like normal cells because stem cells control their growth (Blanpain, 2015). However the contradicting theory is the stochastic model in which all cells have the ability to grow and divide, so the cells that make up a tumor are not organized in any sort of system. I take the stance that tumors are grown through an organized system and that cancer stem cells are at the center of the growth of a tumor instead ofRead MoreEvolutionary Theory Of Natural Selection1164 Words   |  5 Pagesgeneration based on changes in the gene frequency. When changes occur in an individual’s genome, known as mutations, they give the individual different characteristics that can have a negative, positive, or neutral effect. If the mutation better adapts the individual to the environment, that mutation can be passed onto a new generation. If the mutation weakens the individual to the environment, that mutation will not be able to withstand multiple generations through progeny. This mimics Darwin’s theory ofRead MoreThe Human Genome And The Building Blocks Of Life1359 Words   |  6 Pageslearned about mutations and what medical effects they can have on a person. Genetic research allows us to better understand and genetic variation. It has made easier the process of mass producing crops. Because of how useful genetic research is, billions of dollars have been invested in it by companies around the world. But what exactly is behind all of these achievements in biotechnology? In order to understand how the human genome works, it is necessary to understand how a cell works. A cell has eightRead MoreA Study On Lung Cancer1721 Words   |  7 Pagesclinicopathological features and EGFR mutational status in an Indian cohort from a tertiary referral centre. To the best of our knowledge, this is the only paper from Southern India which correlates the exact frequency of each histologic subtype and cell type with the EGFR mutational profile using the WHO 2015 classification of lung tumours reported in the literature to date. Results: Patient Characteristics: The study included 274 patients with primary lung adenocarcinoma. The majority, 186 (67Read MoreGenetic Information And Its Effects On Our Lives836 Words   |  4 Pagesaround us there are mutations; harmful, beneficial and neutral. These changes in genetic information can be helpful to our survival or even lead to our destruction. One common negative mutation that is seen often in our lives is cancer. According to the American Cancer Society an estimate of 585,720 deaths are due to cancer in the US. Cancer might be very deadly but there are ways of treating the mutation. Additionally, there are over a trillion cells on our bodies. These cells can develop abnormallyRead MoreThe Change Of Hemoglobin Changes Essay1210 Words   |  5 Pagespolypeptide chains encoded by genes that attract oxygen molecules to different degrees. 2. The pancreas which has two types of cell clusters. A transcription factor is activated and change the expression of a gene in a way that stimulates some progenitor cells to divide. 3. Proteomics is an area where gene expression emerges. It identifies and analyzes all the proteins that made in a cell, organ, or body. 4. The histone protein plays major role in interacting with other chemical groups which expose DNA and